About INFUSE® Bone Graft
Am I A Candidate?
INFUSE® Bone Graft was tested in a prospective, randomized, large-scale clinical trial involving 279 patients and 16 investigative sites. Patients were randomly selected to receive either INFUSE® Bone Graft or have bone harvested from their hip (autograft) to be placed within the disc space in an anterior lumbar interbody fusion (ALIF) procedure.
The trial achieved its initial goal - proving that INFUSE® Bone Graft is just as effective as traditional surgical techniques that use autograft. During the clinical trial, other advantages surfaced as well. The INFUSE® Bone Graft group lost less blood than autograft recipients. Operating times were shorter. And most notably, rates of fusion were 94.5% in the INFUSE® Bone Graft group and 88.7% in the autograft group at 24 months.
Key findings of the clinical trial with INFUSE® Bone Graft and the LT CAGE® Device include:
- INFUSE® Bone Graft was found to be safe and effective.
- INFUSE® Bone Graft patients showed a slightly higher, though statistically equivalent, fusion rate than the autograft control group.
- Operating times and blood loss were shorter for the INFUSE® Bone Graft patients as compared to the autograft control patients.
- INFUSE® Bone Graft eliminated pain and complications relating to bone harvest.
Many studies have been conducted on INFUSE® Bone Graft. In fact, the product is supported by more level 1 clinical evidence than any other bone graft substitute. Level 1 studies are the most stringent clinical studies because patients are enrolled and randomized into one of two treatment groups before surgery. This makes it possible to compare the outcomes associated with the two treatments.
Below are some relevant journal article citations if you would like to do some further research on INFUSE® Bone Graft.
Burkus JK, Gornet MF, Dickman CA, Zdeblick TA. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech. 2002 Oct;15(5):337-49.
Boden SD, Zdeblick TA, Sandhu HS, Heim SE. The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine. 2000 Feb 1;25(3):376-81.
For more information about INFUSE® Bone Graft, talk to your doctor. To find a doctor who uses INFUSE® Bone Graft, visit our Find A Doctor locator.
It is important that you discuss the potential risks, complications, and benefits of the INFUSE® Bone Graft with your doctor prior to receiving treatment, and that you rely on your physician's judgment. Only your doctor can determine whether you are a suitable candidate for this treatment.