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Home About INFUSE® Bone Graft Clinical Research Am I A Candidate?

About INFUSE® Bone Graft

INFUSE® Bone Graft contains a bone growth protein used in an Anterior Lumbar Interbody Fusion (ALIF) procedure in combination with a titanium threaded cage implant. Using INFUSE® Bone Graft helps reduce the pain and complications associated with treating degenerative disc disease (DDD) by eliminating a second surgery to harvest bone from a patient's own hip (autograft) for transplantation to the spine, as is done in traditional spinal fusion procedures.

The active ingredient in INFUSE® Bone Graft is recombinant human bone morphogenetic protein-2 (rhBMP-2). Bone morphogenetic protein is a manufactured version of a natural protein found in small quantities in the body. The purpose of the protein is to stimulate bone formation.

As mentioned above, INFUSE® Bone Graft is approved for use in spinal fusion in ALIF procedures. Spinal fusion is a surgical method of treating degenerative disc disease after conservative treatments have failed. The procedure stabilizes the spine by fusing two adjacent vertebrae together and helps back pain caused by a degenerated disc in the spine.

To use INFUSE® Bone Graft, surgeons mix the rhBMP-2 powder with sterile water and then apply it to collagen sponges. The sponges are inserted inside a pair of titanium threaded cages, which are then implanted between the vertebrae. The thimble-like cages stabilize the spine while fusion occurs and maintain the proper height between the vertebrae.

For more information about INFUSE® Bone Graft, talk to your doctor. To find a doctor who uses INFUSE® Bone Graft, visit our Find A Doctor locator.


It is important that you discuss the potential risks, complications, and benefits of the INFUSE® Bone Graft with your doctor prior to receiving treatment, and that you rely on your physician's judgment. Only your doctor can determine whether you are a suitable candidate for this treatment.

  • Published: December 07, 2005
  • Updated: June 19, 2013